Experience one of the wonders of the modern world on Holland America Line's Panama Canal cruises. Our Panama cruise itineraries depart from both east and west coasts for loads of convenient options. A cruise to the Panama Canal is an incredible experience, worthy of any bucket list as you travel between oceans. The shipping channel—which took 33 years to complete and cost more than 25,000 workers their lives—is arguably the greatest engineering achievement of all time. As you cruise the canal, you will pass through the two-chambered Miraflores Locks, the one-chambered Pedro Miguel Lock, and three-chambered Gatun Locks. Along the way you'll find Gatun Lake, once the largest manmade lake in the world, which has proved a boon for species that thrive here, undisturbed by the ships passing by.